Fab’entech’s platform is used for the development and manufacturing of immunotherapies composed of highly purified F(ab’)2 fragments of horse specific polyclonal immunoglobulins.
This technology has been developed by Sanofi Pasteur, then in-licensed by Fab'entech.
Such platform having been fully-validated with the development of Fabenflu®, Fab’entech can develop and manufacture, in a short period of time and for limited investments, new immunotherapies from high quality & security standards.
- Herbreteau CH, Denizot M, Lowther S, Riddell S, Frazer L, Haining J, Arkinstall R, Payne J, Harper J, et al. (2016). Efficacy of specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir. Immunotherapy 8(9), 1021-1032.
- Bal C, Herbreteau CH, Buchy P, Rith S, Zaid M, Kristanto W, Han V, Reynaud C, Granjard P, Lepine B, et al. (2015). Safety, potential efficacy, and pharmacokinetics of specific polyclonal immunoglobulin F(ab’)2 fragments against avian influenza A (H5N1) in healthy volunteers: a single-centre, randomised, double-blind, placebo-controlled, phase 1 study. Lancet Infect Dis 15, 285-292.
- Herbreteau CH, Jacquot F, Rith S, Vacher L, Nguyen L, Carbonnelle C, Lotteau V, Jolivet M, Raoul H, Buchy P, et al. (2014). Specific polyclonal F(ab’) neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice. Immunotherapy.
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