Fab’entech’s platform is used for the development and manufacturing of immunotherapies composed of highly purified F(ab’)2 fragments of horse specific polyclonal immunoglobulins.
This technology has been in-licensed by Fab'entech from Sanofi Pasteur.
Thanks to the well-established industrial-scale GMP process of its platform, Fab’entech can develop and manufacture, in a short period of time and for limited investments, new immunotherapies from high quality & security standards.
- Herbreteau CH, Denizot M, Lowther S, Riddell S, Frazer L, Haining J, Arkinstall R, Payne J, Harper J, et al. (2016). Efficacy of specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir. Immunotherapy 8(9), 1021-1032.
- Bal C, Herbreteau CH, Buchy P, Rith S, Zaid M, Kristanto W, Han V, Reynaud C, Granjard P, Lepine B, et al. (2015). Safety, potential efficacy, and pharmacokinetics of specific polyclonal immunoglobulin F(ab’)2 fragments against avian influenza A (H5N1) in healthy volunteers: a single-centre, randomised, double-blind, placebo-controlled, phase 1 study. Lancet Infect Dis 15, 285-292.
- Herbreteau CH, Jacquot F, Rith S, Vacher L, Nguyen L, Carbonnelle C, Lotteau V, Jolivet M, Raoul H, Buchy P, et al. (2014). Specific polyclonal F(ab’) neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice. Immunotherapy.
- Nguyen L. Production d’immunoglobulines thérapeutiques hautement purifiées (ITHP) : analyse d’un procédé de purification. Biologie Aujourd’hui 204, 55–59 (2010).