{"id":1101,"date":"2023-01-01T16:59:39","date_gmt":"2023-01-01T15:59:39","guid":{"rendered":"https:\/\/fabentech.fr\/?p=1101"},"modified":"2023-07-07T17:19:38","modified_gmt":"2023-07-07T15:19:38","slug":"potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern","status":"publish","type":"post","link":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/","title":{"rendered":"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern"},"content":{"rendered":"

The Journal of Infectious Diseases<\/p>\n

Joanna Luczkowiak<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>Pauline Radreau<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Ludovic Nguyen<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Nuria Labiod<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>F\u00e1tima Lasala<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>Francisco Veas<\/a>\u00a0<\/span>3<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>C\u00e9cile H\u00e9l\u00e8ne Herbreteau<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Rafael Delgado<\/a>\u00a0<\/span>1<\/a>\u00a0<\/span>5<\/a>\u00a0<\/span>6<\/a>\u00a0<\/span>7<\/a><\/sup><\/span><\/p>\n

\n

Abstract<\/h2>\n
\n

Several anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs) have received emergency authorization for coronavirus disease 2019 (COVID-19) treatment. However, most of these mAbs are not active against the highly mutated Omicron SARS-CoV-2 subvariants. We have tested a polyclonal approach of equine anti-SARS-CoV-2 F(ab’)2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern tested including Omicron BA.1, BA.2, BA.2.12 and BA.4\/5. A repertoire of antibodies targeting conserved epitopes in different regions of the spike protein could plausibly account for this remarkable breadth of neutralization. These results warrant the clinical investigation of equine polyclonal F(ab’)2 antibodies as a novel therapeutic strategy against COVID-19.<\/p>\n

Keywords: <\/strong>COVID-19; Omicron; SARS-CoV-2; neutralizing antibodies; variants of concern.<\/p>\n

\u00a9 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.<\/p>\n

The Journal of Infectious Diseases<\/em>, Volume 227, Issue 1, 1 January 2023, Pages 35\u201339<\/p>\n<\/div>\n<\/div>\n

Access full publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Journal of Infectious Diseases Joanna Luczkowiak\u00a01,\u00a0Pauline Radreau\u00a02,\u00a0Ludovic Nguyen\u00a02,\u00a0Nuria Labiod\u00a01,\u00a0F\u00e1tima Lasala\u00a01,\u00a0Francisco Veas\u00a03\u00a04,\u00a0C\u00e9cile H\u00e9l\u00e8ne Herbreteau\u00a02,\u00a0Rafael Delgado\u00a01\u00a05\u00a06\u00a07 Abstract Several anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs) have received emergency authorization for coronavirus disease 2019 (COVID-19) treatment. However, most of these mAbs are not active against the highly mutated Omicron SARS-CoV-2 subvariants. We have tested […]<\/p>\n","protected":false},"author":2,"featured_media":1145,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1101","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-papers-en"],"acf":[],"yoast_head":"\nPotent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech<\/title>\n<meta name=\"description\" content=\"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech\" \/>\n<meta property=\"og:description\" content=\"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/\" \/>\n<meta property=\"og:site_name\" content=\"Fabentech\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-01T15:59:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-07T15:19:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1220\" \/>\n\t<meta property=\"og:image:height\" content=\"650\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucile Mairesse De Prades\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucile Mairesse De Prades\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/\",\"url\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/\",\"name\":\"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech\",\"isPartOf\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png\",\"datePublished\":\"2023-01-01T15:59:39+00:00\",\"dateModified\":\"2023-07-07T15:19:38+00:00\",\"author\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4\"},\"description\":\"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern\",\"breadcrumb\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage\",\"url\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png\",\"contentUrl\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png\",\"width\":1220,\"height\":650},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.fabentech.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#website\",\"url\":\"https:\/\/www.fabentech.com\/en\/\",\"name\":\"Fabentech\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.fabentech.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4\",\"name\":\"Lucile Mairesse De Prades\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793\",\"contentUrl\":\"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793\",\"caption\":\"Lucile Mairesse De Prades\"},\"url\":\"https:\/\/www.fabentech.com\/en\/author\/lucile\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech","description":"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/","og_locale":"en_US","og_type":"article","og_title":"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech","og_description":"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern","og_url":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/","og_site_name":"Fabentech","article_published_time":"2023-01-01T15:59:39+00:00","article_modified_time":"2023-07-07T15:19:38+00:00","og_image":[{"width":1220,"height":650,"url":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png","type":"image\/png"}],"author":"Lucile Mairesse De Prades","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lucile Mairesse De Prades","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/","url":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/","name":"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern - Fabentech","isPartOf":{"@id":"https:\/\/www.fabentech.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage"},"image":{"@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage"},"thumbnailUrl":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png","datePublished":"2023-01-01T15:59:39+00:00","dateModified":"2023-07-07T15:19:38+00:00","author":{"@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4"},"description":"We have tested a polyclonal approach of anti-SARS-CoV-2 F(ab')2 antibodies that achieved a high level of neutralizing potency against all SARS-CoV-2 variants of concern","breadcrumb":{"@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#primaryimage","url":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png","contentUrl":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2022\/12\/Journal-of-Infectious-Diseases.png","width":1220,"height":650},{"@type":"BreadcrumbList","@id":"https:\/\/www.fabentech.com\/en\/potent-neutralizing-activity-of-polyclonal-equine-antibodies-against-severe-acute-respiratory-syndrome-coronavirus-2-variants-of-concern\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.fabentech.com\/en\/"},{"@type":"ListItem","position":2,"name":"Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern"}]},{"@type":"WebSite","@id":"https:\/\/www.fabentech.com\/en\/#website","url":"https:\/\/www.fabentech.com\/en\/","name":"Fabentech","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.fabentech.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4","name":"Lucile Mairesse De Prades","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793","contentUrl":"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793","caption":"Lucile Mairesse De Prades"},"url":"https:\/\/www.fabentech.com\/en\/author\/lucile\/"}]}},"_links":{"self":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/comments?post=1101"}],"version-history":[{"count":6,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1101\/revisions"}],"predecessor-version":[{"id":1147,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1101\/revisions\/1147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/media\/1145"}],"wp:attachment":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/media?parent=1101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/categories?post=1101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/tags?post=1101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}