{"id":1121,"date":"2016-07-05T13:48:51","date_gmt":"2016-07-05T11:48:51","guid":{"rendered":"https:\/\/fabentech.fr\/?p=1121"},"modified":"2023-07-07T16:30:26","modified_gmt":"2023-07-07T14:30:26","slug":"efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir","status":"publish","type":"post","link":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/","title":{"rendered":"Efficacy of a specific polyclonal equine F(ab’)2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir"},"content":{"rendered":"

Future Medicine<\/p>\n

C\u00e9cile H Herbreteau<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>M\u00e9lanie Denizot<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>Suzanne Lowther<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Sarah Riddell<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Leah Frazer<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Jessica Haining<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Rachel Arkinstall<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Jean Payne<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Jenni Harper<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Dayna Johnson<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Ana\u00efs Pasquier<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>Deborah Middleton<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Jean-Fran\u00e7ois Saluzzo<\/a>\u00a0<\/span>1<\/a><\/sup><\/span><\/p>\n

\n

Abstract<\/h2>\n
\n

Aim:\u00a0<\/strong>Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.<\/p>\n

Methods:\u00a0<\/strong>Using a ferret model of severe acute H5N1 infection, we assessed FBF-001 when administered on the same day or 1 day after viral challenge, in comparison with oseltamivir therapy.<\/p>\n

Results:\u00a0<\/strong>Untreated animals died 2-3 days after challenge. FBF-001 prevented most severe illness and reduced nasal viral load, with best efficacy when administered on the day of viral challenge. Oseltamivir and FBF-001 had synergistic impact on survival.<\/p>\n

Conclusion:\u00a0<\/strong>FBF-001 prevented severe consequences of lethal H5N1 challenge in ferrets by controlling viral replication, an effect synergistic to oseltamivir. FBF-001 has recently been granted EMA orphan drug status.<\/p>\n<\/div>\n

Keywords:\u00a0<\/strong>A\/H5N1; F(ab’)2; avian influenza; ferret; immunoglobulin; oseltamivir.<\/p>\n

\n

 <\/p>\n<\/div>\n<\/div>\n

Future Medicine<\/em>, Immunotherapy, Vol 8, No 9<\/p>\n

Access full publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Future Medicine C\u00e9cile H Herbreteau\u00a01,\u00a0M\u00e9lanie Denizot\u00a01,\u00a0Suzanne Lowther\u00a02,\u00a0Sarah Riddell\u00a02,\u00a0Leah Frazer\u00a02,\u00a0Jessica Haining\u00a02,\u00a0Rachel Arkinstall\u00a02,\u00a0Jean Payne\u00a02,\u00a0Jenni Harper\u00a02,\u00a0Dayna Johnson\u00a02,\u00a0Ana\u00efs Pasquier\u00a01,\u00a0Deborah Middleton\u00a02,\u00a0Jean-Fran\u00e7ois Saluzzo\u00a01 Abstract Aim:\u00a0Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1. Methods:\u00a0Using a ferret model of severe acute H5N1 infection, we assessed FBF-001 when administered on the […]<\/p>\n","protected":false},"author":2,"featured_media":1160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1121","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-papers-en"],"acf":[],"yoast_head":"\nEfficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech<\/title>\n<meta name=\"description\" content=\"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech\" \/>\n<meta property=\"og:description\" content=\"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/\" \/>\n<meta property=\"og:site_name\" content=\"Fabentech\" \/>\n<meta property=\"article:published_time\" content=\"2016-07-05T11:48:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-07T14:30:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2245\" \/>\n\t<meta property=\"og:image:height\" content=\"1494\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucile Mairesse De Prades\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucile Mairesse De Prades\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/\",\"url\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/\",\"name\":\"Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech\",\"isPartOf\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png\",\"datePublished\":\"2016-07-05T11:48:51+00:00\",\"dateModified\":\"2023-07-07T14:30:26+00:00\",\"author\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4\"},\"description\":\"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage\",\"url\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png\",\"contentUrl\":\"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png\",\"width\":2245,\"height\":1494},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.fabentech.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Efficacy of a specific polyclonal equine F(ab’)2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#website\",\"url\":\"https:\/\/www.fabentech.com\/en\/\",\"name\":\"Fabentech\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.fabentech.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4\",\"name\":\"Lucile Mairesse De Prades\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793\",\"contentUrl\":\"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793\",\"caption\":\"Lucile Mairesse De Prades\"},\"url\":\"https:\/\/www.fabentech.com\/en\/author\/lucile\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech","description":"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/","og_locale":"en_US","og_type":"article","og_title":"Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech","og_description":"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.","og_url":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/","og_site_name":"Fabentech","article_published_time":"2016-07-05T11:48:51+00:00","article_modified_time":"2023-07-07T14:30:26+00:00","og_image":[{"width":2245,"height":1494,"url":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png","type":"image\/png"}],"author":"Lucile Mairesse De Prades","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lucile Mairesse De Prades","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/","url":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/","name":"Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir - Fabentech","isPartOf":{"@id":"https:\/\/www.fabentech.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage"},"image":{"@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage"},"thumbnailUrl":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png","datePublished":"2016-07-05T11:48:51+00:00","dateModified":"2023-07-07T14:30:26+00:00","author":{"@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4"},"description":"Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.","breadcrumb":{"@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#primaryimage","url":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png","contentUrl":"https:\/\/www.fabentech.com\/wp-content\/uploads\/2014\/07\/Future-Medicine.png","width":2245,"height":1494},{"@type":"BreadcrumbList","@id":"https:\/\/www.fabentech.com\/en\/efficacy-of-a-specific-polyclonal-equine-fab2-against-avian-influenza-h5n1-in-ferrets-synergy-with-oseltamivir\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.fabentech.com\/en\/"},{"@type":"ListItem","position":2,"name":"Efficacy of a specific polyclonal equine F(ab’)2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir"}]},{"@type":"WebSite","@id":"https:\/\/www.fabentech.com\/en\/#website","url":"https:\/\/www.fabentech.com\/en\/","name":"Fabentech","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.fabentech.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/82290e21ff7c92ffbc17b891711fb7f4","name":"Lucile Mairesse De Prades","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fabentech.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793","contentUrl":"https:\/\/www.fabentech.com\/wp-content\/litespeed\/avatar\/d4a490a9d73d6636c0923d72fb88747c.jpg?ver=1775009793","caption":"Lucile Mairesse De Prades"},"url":"https:\/\/www.fabentech.com\/en\/author\/lucile\/"}]}},"_links":{"self":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/comments?post=1121"}],"version-history":[{"count":4,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1121\/revisions"}],"predecessor-version":[{"id":1164,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/posts\/1121\/revisions\/1164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/media\/1160"}],"wp:attachment":[{"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/media?parent=1121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/categories?post=1121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fabentech.com\/en\/wp-json\/wp\/v2\/tags?post=1121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}