{"id":1123,"date":"2014-07-21T13:58:30","date_gmt":"2014-07-21T11:58:30","guid":{"rendered":"https:\/\/fabentech.fr\/?p=1123"},"modified":"2023-07-07T16:28:32","modified_gmt":"2023-07-07T14:28:32","slug":"specific-polyclonal-fab2-neutralize-a-large-panel-of-highly-pathogenic-avian-influenza-a-viruses-h5n1-and-control-infection-in-mice","status":"publish","type":"post","link":"https:\/\/www.fabentech.com\/en\/specific-polyclonal-fab2-neutralize-a-large-panel-of-highly-pathogenic-avian-influenza-a-viruses-h5n1-and-control-infection-in-mice\/","title":{"rendered":"Specific polyclonal F(ab’)2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice"},"content":{"rendered":"

Future Medicine<\/p>\n

C\u00e9cile H\u00e9l\u00e8ne Herbreteau<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span>Fr\u00e9d\u00e9ric Jacquot<\/a>,\u00a0<\/span>Sareth Rith<\/a>,\u00a0<\/span>Laurent Vacher<\/a>,\u00a0<\/span>Ludovic Nguyen<\/a>,\u00a0<\/span>Caroline Carbonnelle<\/a>,\u00a0<\/span>Vincent Lotteau<\/a>,\u00a0<\/span>Michel Jolivet<\/a>,\u00a0<\/span>Herv\u00e9 Raoul<\/a>,\u00a0<\/span>Philippe Buchy<\/a>,\u00a0<\/span>Jean-Fran\u00e7ois Saluzzo<\/a><\/span><\/p>\n

\n

Abstract<\/h2>\n
\n

Aim:\u00a0<\/strong>There is still no specific therapy for infection with the highly pathogenic avian influenza A virus (HPAI) H5N1, which caused 39 human cases with a 64% fatality rate in 2013.<\/p>\n

Materials & methods:\u00a0<\/strong>We prepared highly purified specific equine polyclonal immunoglobulin fragments (F(ab’)2) against H5N1 and tested them for efficacy in vitro and with different administration schedules in H5N1-challenged BALB\/c mice.<\/p>\n

Results:\u00a0<\/strong>in vitro, F(ab’)2 neutralized 21 different H5N1 strains from different areas, representative of 11 different clades and sub-clades and 9 years of evolution of the virus. In vivo mouse experiments identified that the most efficient administration protocol consists of five consecutive daily injections after infection; 10 mg\/kg giving a 60% increase in survival.<\/p>\n

Conclusion:\u00a0<\/strong>These data demonstrate the ability of anti-H5N1 F(ab’)2 to markedly reduce the mortality and morbidity associated with infection of mice with HPAI H5N1 virus, and their potential for human therapy.<\/p>\n<\/div>\n

Keywords:\u00a0<\/strong>F(ab\u2019)2; Fabenflu\u00ae; H5N1; immunoglobulin; influenza; passive immunotherapy.<\/p>\n

Future Medicine<\/em>, Immunotherapy, Vol 6, No 6<\/p>\n

\n

Access full publication<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Future Medicine C\u00e9cile H\u00e9l\u00e8ne Herbreteau\u00a01,\u00a0Fr\u00e9d\u00e9ric Jacquot,\u00a0Sareth Rith,\u00a0Laurent Vacher,\u00a0Ludovic Nguyen,\u00a0Caroline Carbonnelle,\u00a0Vincent Lotteau,\u00a0Michel Jolivet,\u00a0Herv\u00e9 Raoul,\u00a0Philippe Buchy,\u00a0Jean-Fran\u00e7ois Saluzzo Abstract Aim:\u00a0There is still no specific therapy for infection with the highly pathogenic avian influenza A virus (HPAI) H5N1, which caused 39 human cases with a 64% fatality rate in 2013. Materials & methods:\u00a0We prepared highly purified specific equine polyclonal […]<\/p>\n","protected":false},"author":2,"featured_media":1160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1123","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-papers-en"],"acf":[],"yoast_head":"\nSpecific polyclonal F(ab')2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice - Fabentech<\/title>\n<meta name=\"description\" content=\"There is still no specific therapy for infection with the highly pathogenic avian influenza A virus (HPAI) H5N1, which caused 39 human cases with a 64% fatality rate in 2013.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fabentech.com\/en\/specific-polyclonal-fab2-neutralize-a-large-panel-of-highly-pathogenic-avian-influenza-a-viruses-h5n1-and-control-infection-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Specific polyclonal F(ab')2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice - 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