{"id":1133,"date":"2019-07-01T14:14:50","date_gmt":"2019-07-01T12:14:50","guid":{"rendered":"https:\/\/fabentech.fr\/?p=1133"},"modified":"2023-07-07T16:08:53","modified_gmt":"2023-07-07T14:08:53","slug":"in-vitro-characterization-and-in-vivo-effectiveness-of-ebola-virus-specific-equine-polyclonal-fab2","status":"publish","type":"post","link":"https:\/\/www.fabentech.com\/en\/in-vitro-characterization-and-in-vivo-effectiveness-of-ebola-virus-specific-equine-polyclonal-fab2\/","title":{"rendered":"In Vitro Characterization and In Vivo Effectiveness of Ebola Virus Specific Equine Polyclonal F(ab’)2"},"content":{"rendered":"

The Journal of Infectious Diseases<\/p>\n

Trina Racine<\/a>\u00a0<\/span>1<\/a>\u00a0<\/span>2<\/a>\u00a0<\/span>3<\/a><\/sup>,\u00a0<\/span><\/span>M\u00e9lanie Denizot<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>Delphine Pannetier<\/a>\u00a0<\/span>5<\/a><\/sup>,\u00a0<\/span><\/span>Ludovic Nguyen<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>Ana\u00efs Pasquier<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>Herv\u00e9 Raoul<\/a>\u00a0<\/span>5<\/a><\/sup>,\u00a0<\/span><\/span>Jean-Fran\u00e7ois Saluzzo<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>Gary Kobinger<\/a>\u00a0<\/span>2<\/a>\u00a0<\/span>6<\/a>\u00a0<\/span>3<\/a>\u00a0<\/span>7<\/a><\/sup>,\u00a0<\/span><\/span>Francisco Veas<\/a>\u00a0<\/span>8<\/a><\/sup>,\u00a0<\/span><\/span>C\u00e9cile H Herbreteau<\/a>\u00a0<\/span>4<\/a><\/sup><\/span><\/p>\n

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Abstract<\/h2>\n
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There is no vaccine or approved therapy against lethal Ebola virus (EBOV). We investigated a proven technology platform to produce polyclonal IgG fragments, F(ab’)2, against EBOV. Horses immunized with nanoparticles harboring surface glycoprotein trimers of EBOV-Zaire\/Makona produced anti-Ebola IgG polyclonal antibodies with high neutralization activity. Highly purified equine anti-Ebola F(ab’)2 showed strong cross-neutralization of 2 Zaire EBOV strains (Gabon 2001 and Makona) and in vivo 3 or 5 daily F(ab’)2 intraperitoneal injections provided 100% protection to BALB\/c mice against lethal EBOV challenge. Rapid preparation of purified equine anti-Ebola F(ab’)2 offers a potentially efficient therapeutic approach against EBOV disease in humans.<\/p>\n<\/div>\n

Keywords:\u00a0<\/strong>Ebola; F(ab\u2032)2 fragments; equine; immunoglobulins.<\/p>\n

\u00a9 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.<\/p>\n

The Journal of Infectious Diseases<\/em>, Volume 220, Issue 1, 1 July 2019, Pages 41\u201345<\/p>\n<\/div>\n<\/div>\n

Access full publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Journal of Infectious Diseases Trina Racine\u00a01\u00a02\u00a03,\u00a0M\u00e9lanie Denizot\u00a04,\u00a0Delphine Pannetier\u00a05,\u00a0Ludovic Nguyen\u00a04,\u00a0Ana\u00efs Pasquier\u00a04,\u00a0Herv\u00e9 Raoul\u00a05,\u00a0Jean-Fran\u00e7ois Saluzzo\u00a04,\u00a0Gary Kobinger\u00a02\u00a06\u00a03\u00a07,\u00a0Francisco Veas\u00a08,\u00a0C\u00e9cile H Herbreteau\u00a04 Abstract There is no vaccine or approved therapy against lethal Ebola virus (EBOV). We investigated a proven technology platform to produce polyclonal IgG fragments, F(ab’)2, against EBOV. Horses immunized with nanoparticles harboring surface glycoprotein trimers of EBOV-Zaire\/Makona produced […]<\/p>\n","protected":false},"author":2,"featured_media":1145,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-papers-en"],"acf":[],"yoast_head":"\nIn Vitro Characterization and In Vivo Effectiveness of Ebola Virus Specific Equine Polyclonal F(ab')2 - Fabentech<\/title>\n<meta name=\"description\" content=\"There is no vaccine or approved therapy against lethal Ebola virus (EBOV). 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